Abstract
A novel one-pot protocol for the synthesis of substituted guanidines was developed. The reaction involved guanylation of amines with isonitriles in the presence of iodine and sodium bicarbonate. This procedure can be applied to the preparation of various substituted guanidines in moderate to good yields.
Keywords: Substituted guanidine, isonitrile, carbonimidoyl diioide, Henry reaction, desulfurizing reagent, dichloromethane, N, N, N- tris (4-nitrophenyl) Guanidine (3a), NMR, mass spectrometry
Letters in Organic Chemistry
Title: Guanylation of Amines with Isonitriles in the Presence of Iodine
Volume: 7 Issue: 7
Author(s): Hui Yu, Meishu Zhang, Wenliang Sun, Yuzhe Li and Rui Gao
Affiliation:
Keywords: Substituted guanidine, isonitrile, carbonimidoyl diioide, Henry reaction, desulfurizing reagent, dichloromethane, N, N, N- tris (4-nitrophenyl) Guanidine (3a), NMR, mass spectrometry
Abstract: A novel one-pot protocol for the synthesis of substituted guanidines was developed. The reaction involved guanylation of amines with isonitriles in the presence of iodine and sodium bicarbonate. This procedure can be applied to the preparation of various substituted guanidines in moderate to good yields.
Export Options
About this article
Cite this article as:
Yu Hui, Zhang Meishu, Sun Wenliang, Li Yuzhe and Gao Rui, Guanylation of Amines with Isonitriles in the Presence of Iodine, Letters in Organic Chemistry 2010; 7 (7) . https://dx.doi.org/10.2174/157017810793362262
DOI https://dx.doi.org/10.2174/157017810793362262 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia
CNS & Neurological Disorders - Drug Targets Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review
Current Topics in Medicinal Chemistry Anti-Shock Garments for Obstetric Hemorrhage
Current Women`s Health Reviews Significance of 1,3,4-Oxadiazole Containing Compounds in New Drug Development
Current Drug Research Reviews Endothelial Dysfunction in Heart Failure: Mechanisms and Therapeutic Approaches
Current Vascular Pharmacology New Insight Into A1 Adenosine Receptors in Diabetes Treatment
Current Pharmaceutical Design Effect of the Antihypertensive Treatment on the Bone Mineral Density and Osteoporotic Fracture
Current Hypertension Reviews Inflammatory Caspases: Targets for Novel Therapies
Current Pharmaceutical Design Effect of Nitric Oxide Synthase Inhibition on Body Temperature Control During Endotoxemic Shock
Current Enzyme Inhibition Subject Index to Volume 4
Current Drug Targets - Cardiovascular & Hematological Disorders Adrenocortical Crisis Triggered by Levothyroxine in an Unrecognized Autoimmune Polyglandular Syndrome Type-2: A Case Report with Review of the Literature
Current Drug Safety Progress in Syntheses of 3-n-Butylphthalide and Its Analogues
Current Organic Chemistry Blood Pressure Control and Diabetic Retinopathy
Current Hypertension Reviews The Use of Biomarkers in Sepsis: A Systematic Review
Current Pharmaceutical Biotechnology Nociceptin /Orphanin FQ Peptide (NOP) Receptor Modulators: An Update in Structure-Activity Relationships
Current Medicinal Chemistry Advances in L-Type Calcium Channel Structures, Functions and Molecular Modeling
Current Medicinal Chemistry C5a, a Therapeutic Target in Sepsis
Recent Patents on Anti-Infective Drug Discovery The Role of Hypocarbia in the Development of Cystic Periventricular Leukomalacia
Current Pediatric Reviews Initiation of Dialysis: A Mini-Review of a Changing Paradigm
Cardiovascular & Hematological Disorders-Drug Targets Drug Reinforcement in a Rat Model of Attention Deficit/Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)
Current Drug Abuse Reviews