Sol Gel Method Performed for Biomedical Products Implementation

A.      P. Chiriac; I.      Neamtu; L.      E. Nita; M.      T. Nistor

doi:10.2174/1389557511009010990

Abstract

Sol – gel technology is an impressive and instructive innovation in science that necessitates a multidisciplinary approach for its important applications in the practice. An important peculiarity of the sol gel technology is the possibility to control the mechanism and kinetics of the chemical reactions, thus monitoring the final structure (particle size, porosity, thin layer thickness) of the materials. The low processing temperature combined with the intrinsic bio-compatibility and environmental friendliness of the implied components makes it an ideal method applied in different biomedical purposes: the synthesis of porous matrices for entrapping of organic and inorganic compounds, sensor molecules, enzymes and many other biological molecules, selective coatings for optical and electrochemical biosensors, stationary phases for chromatography, immunoadsorbent and solid-phase extraction materials, controlled release agents, solid-phase biosynthesis, and unique matrices for biophysical studies. It is therefore the scope of this review to provide a few insights of the recent progresses made in sol-gel-based materials for biomedical applications.

Keywords: Bioencapsulation, biosensor, drug delivery, hybrid composite, medical devices, sol-gel technology, Intrinsic bio-compatibility, Sensor molecules, Immunoadsorbent, Solid-phase biosynthesis, Colloid-chemical processes, Nanochemistry, Gel Synthesis, Precursors, Silanolsilanol condensation, Silanol-ester condensation, Colloidal route, Acid-catalyzed reactions, Base-catalyzed reactions, Biocompatible process, Biomolecules immobilization, Chemical inertness, Optical transparency, Tunable porosity, Bio-recognition agents, Organosiloxane, Silicic acid-derived glasses, Fluid-bed coating, Dip- or spin-coating, Bio-doped hydrogels, Xerogels, Hydrophilic-hydrophobic balances, Filled Composite Sol-Gels, Enzyme (Biocatalysts) Immobilization, Cutinase, Fusarium solani pisi, Tripsin inhibitor, Sol, –, Gel Entrapped Enzymes, Thick-film immobilization, Antibodies Immobilization, Protein Immobilization, Human serum albumin (HAS), Bovine serum albumin (BSA), gel matrix, Dry-aged gels, Anti-thrombotic agents, Anti-proliferative agents, Anesthetic agents, Anti-coagulants, Non-genetic action, Tooth-implants, Knee-implants, Surfacefouling effects, Physical-chemical properties, Bulk gel, (Pt/MWNTs), Total Cholesterol Estimation, Cholesterol esterase, Fluorescence resonance energy transfer (FRET), Carbon Nanotube