Abstract
This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides
Current Organic Synthesis
Title: Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions
Volume: 7 Issue: 4
Author(s): Adam J.M. Burrell and Iain Coldham
Affiliation:
Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides
Abstract: This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
Export Options
About this article
Cite this article as:
J.M. Burrell Adam and Coldham Iain, Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions, Current Organic Synthesis 2010; 7 (4) . https://dx.doi.org/10.2174/157017910791414472
DOI https://dx.doi.org/10.2174/157017910791414472 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Aging Drugs – Prospect of Longer Life?
Current Medicinal Chemistry Phytochemical and Pharmacological Insight on Sesamol: An Updated Review
Current Bioactive Compounds Nanoparticle Therapy for Allergic and Inflammatory Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Flavonoids as Sirtuin Modulators
Current Topics in Medicinal Chemistry Folic Acid, Neurodegenerative and Neuropsychiatric Disease
Current Molecular Medicine Recent Developments in the Synthesis of Antitumor-active Glycyrrhetinic Acid Derivatives
Mini-Reviews in Organic Chemistry Phenotypic Screening for Pharmaceuticals Using Tissue Constructs
Current Pharmaceutical Biotechnology Advances in L-Type Calcium Channel Structures, Functions and Molecular Modeling
Current Medicinal Chemistry Vasopressin in Health and Disease with a Focus on Affective Disorders
Central Nervous System Agents in Medicinal Chemistry Beta-Blockers use for Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Past, Present and Future of Electroanalytical Sensor for Aspirin, Ibuprofen and Paracetamol Detection
Current Pharmaceutical Analysis QSAR and Pharmacophore Analysis of a Series of Piperidinyl Urea Derivatives as hERG Blockers and H3 Antagonists
Current Drug Discovery Technologies Immune Response Towards Snake Venoms
Inflammation & Allergy - Drug Targets (Discontinued) cGMP-Dependent Protein Kinase in Regulation of the Pulmonary Circulation
Current Respiratory Medicine Reviews Targeted Drug Delivery Systems for Lung Macrophages
Current Drug Targets Etanercept Improves Cognitive Performance and Increases eNOS and BDNF Expression During Experimental Vascular Dementia in Streptozotocin- induced Diabetes
Current Neurovascular Research Anabolic Androgenic Steroid (AAS) Related Deaths: Autoptic, Histopathological and Toxicological Findings
Current Neuropharmacology G-protein Dependent Platelet Signaling - Perspectives for Therapy
Current Drug Targets Triple Therapy Versus Dual Antiplatelet Therapy for Patients with Atrial Fibrillation and Acute Coronary Syndromes: A Systematic Literature Review
Current Cardiology Reviews Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Current Medicinal Chemistry