Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

Author(s): Jose Brea, Julio Castro-Palomino, Sandra Yeste, Elena Cubero, Antonio Parraga, Eduardo Dominguez and Maria Isabel Loza

Volume 10, Issue 5, 2010

Page: [493 - 503] Pages: 11

DOI: 10.2174/156802610791111524

Price: $65

Abstract

5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy