Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

Title: Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

Volume: 10 Issue: 5

Author(s): Simon E. Ward and Jeannette M. Watson

Affiliation:

Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor

Abstract: This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

Cite this article as:

Ward Simon E. and Watson Jeannette M., Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111533