Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

Title: Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

Volume: 10 Issue: 5

Author(s): Jose Brea, Julio Castro-Palomino, Sandra Yeste, Elena Cubero, Antonio Parraga, Eduardo Dominguez and Maria Isabel Loza

Affiliation:

Abstract: 5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.

Cite this article as:

Brea Jose, Castro-Palomino Julio, Yeste Sandra, Cubero Elena, Parraga Antonio, Dominguez Eduardo and Loza Maria Isabel, Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111524