Abstract
Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.
Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I
Letters in Organic Chemistry
Title: The First Kinetic Enzymatic Resolution of Methyl Ester of C75
Volume: 7 Issue: 3
Author(s): Kuheli Chakrabarty, Cristina Forzato, Patrizia Nitti, Giuliana Pitacco and Ennio Valentin
Affiliation:
Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I
Abstract: Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.
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Cite this article as:
Chakrabarty Kuheli, Forzato Cristina, Nitti Patrizia, Pitacco Giuliana and Valentin Ennio, The First Kinetic Enzymatic Resolution of Methyl Ester of C75, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112405
DOI https://dx.doi.org/10.2174/157017810791112405 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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