Abstract
Phage display is a powerful technology for selecting and engineering peptides and proteins expressed on the surface of filamentous bacteriophage. The advantages of phage display technology over other research tools and its great potential have been demonstrated by successful application of phage display in diverse fields of biomedical / clinical research. In this review we will describe some recent developments in phage display, including new expression vectors, display formats, bioselection strategies and applications in pharmaceutical biotechnology. We highlight some important applications of phage display to identify disease- and pathogen-specific biomolecules, making particular emphasis on development of phage display-derived preventive and therapeutic vaccines.
Keywords: phage display, phage immunogens
Current Pharmaceutical Biotechnology
Title: Phage Displayed Biomolecules As Preventive and Therapeutic Agents
Volume: 2 Issue: 3
Author(s): K. Manoutcharian, G. Gevorkian, A. Cano and J. C. Almagro
Affiliation:
Keywords: phage display, phage immunogens
Abstract: Phage display is a powerful technology for selecting and engineering peptides and proteins expressed on the surface of filamentous bacteriophage. The advantages of phage display technology over other research tools and its great potential have been demonstrated by successful application of phage display in diverse fields of biomedical / clinical research. In this review we will describe some recent developments in phage display, including new expression vectors, display formats, bioselection strategies and applications in pharmaceutical biotechnology. We highlight some important applications of phage display to identify disease- and pathogen-specific biomolecules, making particular emphasis on development of phage display-derived preventive and therapeutic vaccines.
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Cite this article as:
Manoutcharian K., Gevorkian G., Cano A. and Almagro C. J., Phage Displayed Biomolecules As Preventive and Therapeutic Agents, Current Pharmaceutical Biotechnology 2001; 2 (3) . https://dx.doi.org/10.2174/1389201013378671
DOI https://dx.doi.org/10.2174/1389201013378671 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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