Abstract
Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.
Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole, Isoxazole, Tricyclic isoxazole.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Medicinal Chemistry Perspective of Fused Isoxazole Derivatives
Volume: 16 Issue: 26
Author(s): Mahesh A. Barmade, Prashant R. Murumkar, Mayank Kumar Sharma and Mange Ram Yadav
Affiliation:
Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole, Isoxazole, Tricyclic isoxazole.
Abstract: Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.
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Cite this article as:
Barmade A. Mahesh, Murumkar R. Prashant, Sharma Kumar Mayank and Yadav Ram Mange, Medicinal Chemistry Perspective of Fused Isoxazole Derivatives, Current Topics in Medicinal Chemistry 2016; 16 (26) . https://dx.doi.org/10.2174/1568026616666160506145700
DOI https://dx.doi.org/10.2174/1568026616666160506145700 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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