Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?

Author(s): Sara Calatayud, Angeles Alvarez and Victor M. Victor

Volume 10, Issue 1, 2010

Page: [8 - 19] Pages: 12

DOI: 10.2174/138955710791112532

Price: $65

Abstract

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

Keywords: Gastrin, inflammation, immunomodulation, CCK-2 receptors, CCK-2 receptor antagonists


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy