Abstract
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.
Keywords: Gastrin, inflammation, immunomodulation, CCK-2 receptors, CCK-2 receptor antagonists
Mini-Reviews in Medicinal Chemistry
Title: Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?
Volume: 10 Issue: 1
Author(s): Sara Calatayud, Angeles Alvarez and Victor M. Victor
Affiliation:
Keywords: Gastrin, inflammation, immunomodulation, CCK-2 receptors, CCK-2 receptor antagonists
Abstract: Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.
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Cite this article as:
Calatayud Sara, Alvarez Angeles and M. Victor Victor, Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?, Mini-Reviews in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/138955710791112532
DOI https://dx.doi.org/10.2174/138955710791112532 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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