Abstract
Peripheral arterial disease (PAD) is a progressive disease most often due to atherosclerosis and characterized by obstruction of arterial blood flow in the lower limbs. The defining symptom of PAD, intermittent claudication, is evident in only a minority of patients, leading to frequent underdiagnosis. Patients with PAD are more likely to suffer from polyvascular disease than patients with other cardiovascular conditions and have an increased risk of cardiovascular death and ischemic events. This review considers current PAD awareness and treatment, including important findings from the REduction of Atherothrombosis for Continued Health (REACH) and PAD Awareness, Risk and Treatment: New Resources for Survival (PARTNERS) registries. Information on simple diagnostic tools to aid early PAD detection and therapeutic options for global atherosclerosis risk factor management are also presented.
Keywords: Peripheral arterial disease, cardiovascular disease, atherosclerosis, secondary prevention, ankle-brachial index
Current Vascular Pharmacology
Title: The Importance of Early Diagnosis and Treatment in Peripheral Arterial Disease: Insights from the PARTNERS and REACH Registries
Volume: 8 Issue: 3
Author(s): Debabrata Mukherjee and Kim Eagle
Affiliation:
Keywords: Peripheral arterial disease, cardiovascular disease, atherosclerosis, secondary prevention, ankle-brachial index
Abstract: Peripheral arterial disease (PAD) is a progressive disease most often due to atherosclerosis and characterized by obstruction of arterial blood flow in the lower limbs. The defining symptom of PAD, intermittent claudication, is evident in only a minority of patients, leading to frequent underdiagnosis. Patients with PAD are more likely to suffer from polyvascular disease than patients with other cardiovascular conditions and have an increased risk of cardiovascular death and ischemic events. This review considers current PAD awareness and treatment, including important findings from the REduction of Atherothrombosis for Continued Health (REACH) and PAD Awareness, Risk and Treatment: New Resources for Survival (PARTNERS) registries. Information on simple diagnostic tools to aid early PAD detection and therapeutic options for global atherosclerosis risk factor management are also presented.
Export Options
About this article
Cite this article as:
Mukherjee Debabrata and Eagle Kim, The Importance of Early Diagnosis and Treatment in Peripheral Arterial Disease: Insights from the PARTNERS and REACH Registries, Current Vascular Pharmacology 2010; 8 (3) . https://dx.doi.org/10.2174/157016110791112304
DOI https://dx.doi.org/10.2174/157016110791112304 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Remodeling of the Insulin Receptor Pathway by Thiazolidinediones in Type 2 Diabetes Mellitus: A Brief Review
Protein & Peptide Letters Inflammatory Bowel Disease: New Therapeutic Options in the Post Anti-TNFα Era
Current Drug Metabolism Radionuclide PET and PET/CT in Coronary Artery Disease
Current Pharmaceutical Design Patent Selections
Recent Patents on Cardiovascular Drug Discovery Nanotechnology and Alzheimer's Disease: What has been Done and What to Do'
Current Medicinal Chemistry Recent Advances in Treatment Approaches of Mucopolysaccharidosis VI
Current Pharmaceutical Biotechnology Patent Annotations
Recent Patents on Anti-Infective Drug Discovery Thiazolidinediones and Cardiovascular Risk — A Question of Balance
Current Cardiology Reviews Recent Patents in Olive Oil Industry: New Technologies for the Recovery of Phenols Compounds from Olive Oil, Olive Oil Industrial by-Products and Waste Waters
Recent Patents on Food, Nutrition & Agriculture Statins in Bacteremia, Sepsis and Pneumonia: Have We Found the Holy Grail?
Recent Patents on Inflammation & Allergy Drug Discovery Levosimendan: From Basic Science to Clinical Trials
Recent Patents on Cardiovascular Drug Discovery Preclinical Testing of Drug-Induced Proarrhythmia: Value of Transgenic Models
Cardiovascular & Hematological Agents in Medicinal Chemistry iMethylK-PseAAC: Improving Accuracy of Lysine Methylation Sites Identification by Incorporating Statistical Moments and Position Relative Features into General PseAAC via Chou’s 5-steps Rule
Current Genomics Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders
Mini-Reviews in Medicinal Chemistry Docosahexaenoic Acid and Membrane Lipid Domains
Current Organic Chemistry Subject Index To Volume 2
Current Psychiatry Reviews Metabolic Activation of Herbal and Dietary Constituents and Its Clinical and Toxicological Implications: An Update
Current Drug Metabolism Inhibition of the Calcineurin-NFAT Signalling Cascade in the Treatment of Heart Failure
Recent Patents on Cardiovascular Drug Discovery Molecular Pharmacological Approaches to Effects of Capsaicinoids and of Classical Antisecretory Drugs on Gastric Basal Acid Secretion and on Indomethacin-Induced Gastric Mucosal Damage in Human Healthy Subjects (Mini Review)
Current Pharmaceutical Design Desmoteplase for Acute Ischemic Stroke: A Systematic Review and Metaanalysis of Randomized Controlled Trials
CNS & Neurological Disorders - Drug Targets