Abstract
Docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) is the longest chain and most unsaturated fatty acid commonly found in biological systems [1]. It represents the extreme example of the important class of fatty acids known as omega-3s. Primarily through dietary studies, this fatty acid has been linked to an enormous variety of human afflictions including cancer [2, 3], heart disease [4], rheumatoid arthritis [5], lupus [6], alcoholism [7], blindness [8], respiratory diseases [9], peroxisomal disorders [10], cystic fibrosis [11], schizophrenia [12], depression [13], malaria [14], multiple sclerosis [15] and even migrane headaches. In order for one simple molecule to affect so many seemingly unrelated processes it must function at a fundamental level, common to most cells. It has been suggested that this level is in controlling membrane structure and function [16]. Due to its extreme chain length and unsaturation it should be easier to demonstrate a unique role for DHA in membrane structure/function than it will be for other shorter, less unsaturated fatty acids commonly found in membranes. Reviewed here is the possible involvement of DHA in membrane lipid domains.
Current Organic Chemistry
Title: Docosahexaenoic Acid and Membrane Lipid Domains
Volume: 4 Issue: 11
Author(s): William Stillwell
Affiliation:
Abstract: Docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) is the longest chain and most unsaturated fatty acid commonly found in biological systems [1]. It represents the extreme example of the important class of fatty acids known as omega-3s. Primarily through dietary studies, this fatty acid has been linked to an enormous variety of human afflictions including cancer [2, 3], heart disease [4], rheumatoid arthritis [5], lupus [6], alcoholism [7], blindness [8], respiratory diseases [9], peroxisomal disorders [10], cystic fibrosis [11], schizophrenia [12], depression [13], malaria [14], multiple sclerosis [15] and even migrane headaches. In order for one simple molecule to affect so many seemingly unrelated processes it must function at a fundamental level, common to most cells. It has been suggested that this level is in controlling membrane structure and function [16]. Due to its extreme chain length and unsaturation it should be easier to demonstrate a unique role for DHA in membrane structure/function than it will be for other shorter, less unsaturated fatty acids commonly found in membranes. Reviewed here is the possible involvement of DHA in membrane lipid domains.
Export Options
About this article
Cite this article as:
Stillwell William, Docosahexaenoic Acid and Membrane Lipid Domains, Current Organic Chemistry 2000; 4 (11) . https://dx.doi.org/10.2174/1385272003375860
DOI https://dx.doi.org/10.2174/1385272003375860 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Casein Phosphopeptides in Oral Health - Chemistry and Clinical Applications
Current Pharmaceutical Design New Insights into HLA-G and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Global Account of Barriers and Facilitators of Physical Activity Among Patients with Diabetes Mellitus: A Narrative Review of the Literature
Current Diabetes Reviews ACE Inhibitor Delapril Prevents Ca<sup>2+</sup>-Dependent Blunting of I<sub>K1</sub> and Ventricular Arrhythmia in Ischemic Heart Disease
Current Molecular Medicine Cardioprotective Effect of Resveratrol and Resveratroloside
Cardiovascular & Hematological Agents in Medicinal Chemistry Virtual Screening Against Obesity
Current Medicinal Chemistry Mesenchymal Stem Cell Therapy for Ischemic Heart Disease: Advances and Challenges
Current Pharmaceutical Design Anti Inflammatory and Anti Arthritic Activity of Different Milk Based Formulation of Curcumin in Rat Model
Current Drug Delivery Anti-Inflammatory Agents from Plants: Progress and Potential
Current Medicinal Chemistry Effect of Aging On Angiogenesis and Arteriogenesis
Current Cardiology Reviews From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors
Current Topics in Medicinal Chemistry Coil-to-Helix Transition within Phospholamban Underlies Release of Ca- ATPase Inhibition in Response to β-Adrenergic Signaling
Current Enzyme Inhibition Therapeutic Proteins and Nanotechnology: Immune Response and Stealth Bioengineered Constructs
Current Drug Metabolism Can Dietary Polyphenols Prevent the Formation of Toxic Compounds from Maillard Reaction?
Current Drug Metabolism Serum Collagen Markers and Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets Association between Paraoxonase 1(PON1) Gene Polymorphisms and PON1 Enzyme Activity in Indian Patients with Coronary Artery Disease (CAD)
Current Pharmacogenomics and Personalized Medicine Key Proteins in the Polyamine-Trypanothione Pathway as Drug Targets Against Trypanosoma cruzi
Current Medicinal Chemistry Editorial: Vascular Calcification, Cardiovascular Risk and microRNAs
Current Vascular Pharmacology Acute Cerebral Blood Flow Variations after Human Cardiac Arrest Assessed by Stable Xenon Enhanced Computed Tomography
Current Neurovascular Research Formulation and In Vivo Evaluation of Ticagrelor Self-nanoemulsifying Drug Delivery Systems
Pharmaceutical Nanotechnology