Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay

Title: Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay

Volume: 9 Issue: 13

Author(s): Yuli Xie, Alison Rinderspacher, Yidong Liu, Gangli Gong, Deborah H. Smith, Michael Wyler, Lars Branden and Shi-Xian Deng

Affiliation:

Abstract: Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-κB regulators. This review will discuss the inhibitors and activators newly discovered by Columbias Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.

Cite this article as:

Xie Yuli, Rinderspacher Alison, Liu Yidong, Gong Gangli, Smith H. Deborah, Wyler Michael, Branden Lars and Deng Shi-Xian, Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay, Current Topics in Medicinal Chemistry 2009; 9 (13) . https://dx.doi.org/10.2174/156802609789753617