Abstract
Resorcinarenes constitute a very attractive class of macrocycles possessing a cavity capable of complexing small molecules. They can be simply transformed into chiral derivatives by functionalisation of their hydroxy groups as well as the “ortho” position at the resorcinol ring. The appropriate modifications lead to various chiral resorcinarene derivatives. The chirality of these compounds results from their structure (the axial chirality) or from the presence of chiral auxiliaries. Moreover, the synthesis of chiral resorcinarene derivatives from chiral substrates is also possible. In this short review, we wish to present the strategies and methodology of the synthesis of chiral resorcinarenes, treating this article as an introduction to the chirality of resorcinarenes.
Keywords: Calixarene, Resorcinarene, Chirality, Symmetry
Mini-Reviews in Organic Chemistry
Title: Introduction to the Chirality of Resorcinarenes
Volume: 6 Issue: 4
Author(s): Waldemar Iwanek and Alicja Wzorek
Affiliation:
Keywords: Calixarene, Resorcinarene, Chirality, Symmetry
Abstract: Resorcinarenes constitute a very attractive class of macrocycles possessing a cavity capable of complexing small molecules. They can be simply transformed into chiral derivatives by functionalisation of their hydroxy groups as well as the “ortho” position at the resorcinol ring. The appropriate modifications lead to various chiral resorcinarene derivatives. The chirality of these compounds results from their structure (the axial chirality) or from the presence of chiral auxiliaries. Moreover, the synthesis of chiral resorcinarene derivatives from chiral substrates is also possible. In this short review, we wish to present the strategies and methodology of the synthesis of chiral resorcinarenes, treating this article as an introduction to the chirality of resorcinarenes.
Export Options
About this article
Cite this article as:
Iwanek Waldemar and Wzorek Alicja, Introduction to the Chirality of Resorcinarenes, Mini-Reviews in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157019309789371604
DOI https://dx.doi.org/10.2174/157019309789371604 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Realizing the Potential of Health-Promoting Rosehips from Dogroses (Rosa sect. Caninae)
Current Bioactive Compounds Purification and Characterization of Nitric Oxide Synthase from Bovine Kidney and Investigating Drug-Induced Toxicities of Some Antibiotics on the Enzyme Activity
Current Enzyme Inhibition Cationic <i>Clitoria ternatea</i> Seed Peptide as a Potential Novel Bioactive Molecule
Protein & Peptide Letters Systemic Sclerosis: From Pathogenesis Towards Targeted Immunotherapies
Current Rheumatology Reviews A Hybrid Discrete Imperialist Competition Algorithm for Gene Selection for Microarray Data
Current Proteomics Anti-Inflammatory Drugs in Psychiatry
Inflammation & Allergy - Drug Targets (Discontinued) Classifications and Clinical Assessment of Haemorrhoids: The Proctologist’s Corner
Reviews on Recent Clinical Trials Sodium Carbonate Sesquiperhydrate (2Na2CO3-3H2O2) Catalysed One-pot Synthesis of Biologically Dynamic Novel Substituted Spirooxirane Dicarboxamides
Current Catalysis Molecular Origin of Color Variation in Firefly (Beetle) Bioluminescence: A Chemical Basis for Biological Imaging
Current Topics in Medicinal Chemistry Novel Spiro/non-Spiro Pyranopyrazoles: Eco-Friendly Synthesis, In-vitro Anticancer Activity, DNA Binding, and In-silico Docking Studies
Current Bioactive Compounds NRF2-Dependent Glutamate-L-Cysteine Ligase Catalytic Subunit Expression Mediates Insulin Protection Against Hyperglycemia-Induced Brain Endothelial Cell Apoptosis
Current Neurovascular Research Withdrawal Notice: Characterization of Glyoxal Modified LDL: Role in the Generation of Circulating Autoantibodies in Type 2 Diabetes Mellitus and Coronary Artery Disease
Current Drug Targets Aryl- and Heteroaryl-Thiosemicarbazone Derivatives and Their Metal Complexes: A Pharmacological Template
Recent Patents on Anti-Cancer Drug Discovery Label-Free Cell Phenotypic Drug Discovery
Combinatorial Chemistry & High Throughput Screening Drug Delivery Systems with Modified Release for Systemic and Biophase Bioavailability
Current Clinical Pharmacology Recent Studies on Design and Development of Drugs Against Alzheimer’s Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents
Current Topics in Medicinal Chemistry Seeing the Light: Luminescent Reporter Gene Assays
Combinatorial Chemistry & High Throughput Screening Computer-Aided Drug Design of Bioactive Natural Products
Current Topics in Medicinal Chemistry The Ability of Tolfenamic Acid to Penetrate the Brain: A Model for Testing the Brain Disposition of Candidate Alzheimers Drugs Using Multiple Platforms
Current Alzheimer Research Facile Microwave-assisted Synthesis of Various C5-modified Pyrimidine Pyranonucleosides as Potential Cytotoxic Antitumor Agents
Current Microwave Chemistry