Interplay of Carotenoids with Cigarette Smoking: Implications in Lung Cancer

Paola      Palozza; Rossella      Simone; Maria   Cristina   Mele

doi:10.2174/092986708783955400

Abstract

The potential for carotenoids to modulate chronic diseases related to smoke is currently under investigation and renewed interest has been placed on achieving a better understanding of the mechanism(s) of action of carotenoids in smoke-exposed biological systems. Available data currently show that, while carotenoids alone are not harmful, their interaction with smoke may shift from beneficial to detrimental depending on the dose, the type of carotenoid as well as the biological environment in which they act. Several mechanisms have been proposed to explain such a shift. They include: (i) changes in cell oxidative status, which tips the β-carotene antioxidantprooxidant balance toward a prooxidant status; (ii) modulation of the levels of key proteins involved in the regulation of cell proliferation and apoptosis; (iii) reduction of retinoic acid signal pathway which down-regulates the RARβ expression and up-regulates AP-1; (iv) interference with absorption of other nutrients at better antioxidant profile; (v) formation of specific carotenoid oxidation products. This review summarizes the available evidences in cultured cells, animal models and humans for a modulatory action of carotenoids on the dangerous effects of smoke and focuses on the main molecular pathways involved in this process.

Keywords: Carotenoids, carotenoid oxidation products and metabolites, cigarette smoke, tar, redox status, DNA adducts, cytochrome P-450, cell signalling