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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Memory-Enhancing Drugs: A Molecular Perspective

Author(s): Barbara Monti and Antonio Contestabile

Volume 9, Issue 7, 2009

Page: [769 - 781] Pages: 13

DOI: 10.2174/138955709788452621

Price: $65

Abstract

Neurodegenerative diseases associated with dementia are characterized by cognitive deficits and memory impairment, thus stimulating research for memory enhancing drugs. We survey here the state of the art of research and clinical trials on these drugs from cholinesterase inhibitors and drugs acting on neurotransmitter receptors to drugs acting on gene expression.

Keywords: Memory, neurodegenerative disease, acetylcholine, AMPA receptor, CREB, chromatin


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