Therapeutic Role of Zonisamide in Neuropsychiatric Disorders

Title: Therapeutic Role of Zonisamide in Neuropsychiatric Disorders

Volume: 8 Issue: 10

Author(s): Muhammad U. Farooq, Philip W. Moore, Archit Bhatt, Rany Aburashed and Mounzer Y. Kassab

Affiliation:

Keywords: zonisamide, seizure disorders, migraine, pain syndromes, movement disorders, neuroprotection, bipolar and anxiety disorders

Abstract: Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinsons disease, essential tremor, stroke, obesity, anxiety, bipolar and bingeeating disorders.

Cite this article as:

Farooq U. Muhammad, Moore W. Philip, Bhatt Archit, Aburashed Rany and Kassab Y. Mounzer, Therapeutic Role of Zonisamide in Neuropsychiatric Disorders, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740643