Abstract
Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.
Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes
Current Bioinformatics
Title: Current Trends in Pseudogene Detection and Characterization
Volume: 4 Issue: 2
Author(s): Eric Christian Rouchka and I. Elizabeth Cha
Affiliation:
Keywords: Pseudogene, gene prediction, disabled pseudogenes, processed pseudogenes, duplicated pseudogenes
Abstract: Pseudogenes are homologous relatives of known genes that have lost their ability to function as a transcriptional unit. Three classes of pseudogenes are known to exist: duplicated pseudogenes; processed or retrotransposed pseudogenes; and unitary or disabled pseudogenes. Since pseudogenes may display a number of the characteristics of functional genes, they pose a unique set of problems for ab initio gene prediction. The ability to detect and differentiate pseudogenes from functional genes can be a difficult task. We present a comprehensive review of current approaches for pseudogene detection, highlighting difficulties in pseudogene differentiation.
Export Options
About this article
Cite this article as:
Rouchka Christian Eric and Cha Elizabeth I., Current Trends in Pseudogene Detection and Characterization, Current Bioinformatics 2009; 4 (2) . https://dx.doi.org/10.2174/157489309788184792
DOI https://dx.doi.org/10.2174/157489309788184792 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Spherical Self-Organizing Map Detects MYBL 1 As Candidate Gene for Triple-Negative Breast Cancer
Neuroscience and Biomedical Engineering (Discontinued) Gene-Gene Interactions in a Context of Individual Variability in Antipsychotic Drug Pharmacogenomics
Current Pharmacogenomics and Personalized Medicine Targeting Lentiviral Vectors for Cancer Immunotherapy
Current Cancer Therapy Reviews Immunomodulatory Activity of Garlic
Current Immunology Reviews (Discontinued) Pharmacogenomics of the Human ATP-Binding Cassette Transporter ABCG2
Current Pharmacogenomics Progress in the Development of Bestatin Analogues as Aminopeptidases Inhibitors
Current Medicinal Chemistry Intriguing Classes of Acridine Derivatives as DNA-binding Antitumour Agents: From Pyrimido[5,6,1-de]acridines to Bis(acridine-4-carboxamides)
Medicinal Chemistry Reviews - Online (Discontinued) Role of FK506 Binding Proteins in Neurodegenerative Disorders
Current Medicinal Chemistry New Promises to Cure Cancer and Other Genetic Diseases/Disorders: Epi-drugs Through Epigenetics
Current Topics in Medicinal Chemistry Role of Flavonoids in Future Anticancer Therapy by Eliminating the Cancer Stem Cells
Current Stem Cell Research & Therapy New Perspectives in Glioma Immunotherapy
Current Pharmaceutical Design Anticancer Agents Derived from Natural Cinnamic Acids
Anti-Cancer Agents in Medicinal Chemistry Erlotinib in Glioblastoma - Lost in Translation?
Anti-Cancer Agents in Medicinal Chemistry Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments
Current Medicinal Chemistry Hsp90: A Novel Target for Cancer Therapy
Current Topics in Medicinal Chemistry Syntheses and Preliminary Evaluation of Dual Target PET Probe [<sup>18</sup>F]-NOTA-Gly3- E (2PEG4-RGD-WH701) for PET Imaging of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Immunological Mechanism and Clinical Application of PAMP Adjuvants
Recent Patents on Anti-Cancer Drug Discovery PROGRAMMED Cell Clearance: Molecular Mechanisms and Role in Autoimmune Disease, Chronic Inflammation, and Anti-Cancer Immune Responses
Current Immunology Reviews (Discontinued) Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Current Drug Metabolism Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications
Current Cancer Drug Targets