Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION)

Title: Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION)

Volume: 6 Issue: 3

Author(s): Xueming Chen, Xiaoguang Huang, Yunyun Chen, Feng He and Xingshu Li

Affiliation:

Keywords: Dihydropyridines, addition-rearrangement, Cu2+-catalyzed, imines, β-ketoester, solvent-free

Abstract: N-substituted 1,4-dihydropyridines bearing a carboxyl group at the 4-position were synthesized in solvent-free conditions with Cu2+ as the catalyst, imine and β-ketoester as starting materials. The possible mechanism which consists of addition-rearrangement process was proposed and examined by the reaction of isolated product of first addition to β- ketoester.

Cite this article as:

Chen Xueming, Huang Xiaoguang, Chen Yunyun, He Feng and Li Xingshu, Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION), Letters in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157017809787893082