Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction

Title: Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction

Volume: 6 Issue: 3

Author(s): Luis S. Astudillo, Margarita Gutierrez C., Hugo Gaete, Vladimir V. Kouznetsov, Carlos M. Melendez, J. Antonio Palenzuela and Gabriel Vallejos G.

Affiliation:

Keywords: 2-Aryl-1,2,3,4-tetrahydroquinolines, microwave-heated three-component Povarov (imino Diels-Alder) reaction, dry media

Abstract: A new series of 2-aryl-1,2,3,4-tetrahydroquinolines has been synthesized in good yields through a BiCl3- catalyzed three-component Povarov reaction (imino Diels-Alder cycloaddition) between anilines, benzaldehydes and Nvinylpyrrolidin- 2-one in MeCN. The same series has been prepared without solvent using microwave radiation, which resulted in better yields, a considerable decrease in reaction times and simplified workup.

Cite this article as:

Astudillo S. Luis, C. Gutierrez Margarita, Gaete Hugo, Kouznetsov V. Vladimir, Melendez M. Carlos, Palenzuela Antonio J. and G. Vallejos Gabriel, Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction, Letters in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157017809787893145