P-gp Transporter and its Role in Neurodegenerative Diseases

Title: P-gp Transporter and its Role in Neurodegenerative Diseases

Volume: 9 Issue: 2

Author(s): Simona Rapposelli, Maria Digiacomo and Aldo Balsamo

Affiliation:

Keywords: P-glycoprotein, Neurodegenerative disorder, Epilepsy, Alzheimer, Parkinson, Hungtington, ALS

Abstract: This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimers (AD), Parkinsons (PD), Huntingtons (HD) and Creutzfeldt-Jakobs (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of Pglycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.

Cite this article as:

Rapposelli Simona, Digiacomo Maria and Balsamo Aldo, P-gp Transporter and its Role in Neurodegenerative Diseases, Current Topics in Medicinal Chemistry 2009; 9 (2) . https://dx.doi.org/10.2174/156802609787521544