Generic placeholder image

Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Structure and Function in COPD

Author(s): Riccardo Pellegrino, Giuseppe Coletta, Valter Gallo and Vito Brusasco

Volume 4, Issue 4, 2008

Page: [235 - 239] Pages: 5

DOI: 10.2174/157339808786263770

Price: $65

Abstract

The recent definition that chronic obstructive pulmonary disease (COPD) is a “preventable and treatable disease state characterized by airflow limitation that is not fully reversible” reminds that the respiratory functional evaluation is an integral part in the diagnostic and follow-up process in this disease. This review has the scope to focus on some of the most debated pathophysiological and functional issues. One of these is how airflow obstruction occurs and progresses. To this aim, we will discuss the functional role of mucus, increased thickness of the submucosa and adventitia, airway smooth muscle, site of airway narrowing, collapsibility of the central airways, and loss of lung elastic recoil in decreasing flow. Then, we will present a functional clinical approach to the disease that covers the most important features of the disease, such as diagnosis, follow-up, severity assessment, lung hyperinflation, and bronchodilator response.

Keywords: Airflow limitation, airway narrowing, lung elastic recoil, lung hyperinflation, bronchodilation, pathology, lung function tests


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy