Therapeutic Potential of Voltage Gated Calcium Channels

Title: Therapeutic Potential of Voltage Gated Calcium Channels

Volume: 8 Issue: 12

Author(s): C. Gopi Mohan and Tamanna Gandhi

Affiliation:

Keywords: Calcium, Voltage gated channel, L-type channel, T-type channel, dihydropyridine

Abstract: Voltage-gated Calcium channels (VGCCs) play important roles in neurotransmitter release, excitationcontraction coupling, hormone secretion, and a variety of other physiological processes. Currently, there exist ion channel therapeutics for anxiety, epilepsy, hypertension, insomnia and pain. There is limited amount of study in this area despite their relevance to human disease and VGCCs remain considerably underexploited. The present review mainly focuses on calcium channel blockers (CCBs), especially for L-type channels and T-type channels, and therein lie some of the opportunities and advantages associated with VGCCs as drug targets.

Cite this article as:

Mohan Gopi C. and Gandhi Tamanna, Therapeutic Potential of Voltage Gated Calcium Channels, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786141016