Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents

Title:Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents

Volume: 9 Issue: 4

Author(s): Basant Kumar Singh, Narsingh Sachan and Pooja Chawla

Affiliation:

Keywords: Anticonvulsant, convulsion, MES, pharmacophore, pyrazol-5-one.

Abstract: Two series of novel 1-(4-substitutedbenzoyl)-3-((2-oxoimidazolin-1-yl)methyl)-1H-pyrazol-5(4H)-one, 1- methyl-3-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)methyl)urea,1-((1-(4-substitutedbenzoyl)-5-oxo- 4,5-dihydro-1H-pyrazol-3-yl)methyl) thio urea and 1-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3- yl)methyl)-3-phenyl thiourea were synthesized and characterized by IR, mass, ¹HNMR spectroscopic techniques. The synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) model. Among the newly synthesized compounds, most of the compounds showed significant activity and 1C₂ emerged as the most active analogue.

Cite this article as:

Singh Kumar Basant, Sachan Narsingh and Chawla Pooja, Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents, Current Bioactive Compounds 2013; 9 (4) . https://dx.doi.org/10.2174/1573407210666140307011414