Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine

Title: Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine

Volume: 8 Issue: 3

Author(s): Jianfeng Zhang and De-chu C. Tang

Affiliation:

Keywords: Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization

Abstract: The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.

Cite this article as:

Zhang Jianfeng and Tang C. De-chu, Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine, Infectious Disorders - Drug Targets 2008; 8 (3) . https://dx.doi.org/10.2174/1871526510808030189