Abstract
Forty-two 3-substituted 1-(5-formylfurfuryl)indolin-2-ones were synthesized and most of these compounds exhibited potent inhibitory activities against P. oryzae (MIC = 0.78-25 μg/mL) and human intestinal Caco-2 cells (IC50 = 0.19-9.42 μM). Eight compounds selected for further screening also showed inhibitory activities (IC50 = 1.84-10.32 μM) against human lung adenocarcinoma cells (SPC-A1).
Keywords: 3-Substituted 1-(5-formylfurfuryl)indolin-2-ones, antitumor activity, antifungal activity, Pyricoraria oryzae, Caco-2 cells, SPC-A1
Letters in Organic Chemistry
Title: Synthesis and Antitumor Activities of 3-Substituted 1-(5-formylfurfuryl)indolin-2-one Derivatives
Volume: 4 Issue: 8
Author(s): Fusheng Zhou, Jianbin Zheng, Xiaochun Dong, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Lin Li and Ren Wen
Affiliation:
Keywords: 3-Substituted 1-(5-formylfurfuryl)indolin-2-ones, antitumor activity, antifungal activity, Pyricoraria oryzae, Caco-2 cells, SPC-A1
Abstract: Forty-two 3-substituted 1-(5-formylfurfuryl)indolin-2-ones were synthesized and most of these compounds exhibited potent inhibitory activities against P. oryzae (MIC = 0.78-25 μg/mL) and human intestinal Caco-2 cells (IC50 = 0.19-9.42 μM). Eight compounds selected for further screening also showed inhibitory activities (IC50 = 1.84-10.32 μM) against human lung adenocarcinoma cells (SPC-A1).
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Cite this article as:
Zhou Fusheng, Zheng Jianbin, Dong Xiaochun, Zhang Zhiwen, Zhao Lingling, Sha Xianyi, Li Lin and Wen Ren, Synthesis and Antitumor Activities of 3-Substituted 1-(5-formylfurfuryl)indolin-2-one Derivatives, Letters in Organic Chemistry 2007; 4 (8) . https://dx.doi.org/10.2174/157017807782795484
DOI https://dx.doi.org/10.2174/157017807782795484 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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