The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen

Title: The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen

Volume: 10 Issue: 16

Author(s): A- R. Hanauske, Karen Sundell and Michael Lahn

Affiliation:

Keywords: pkc, protein kinase c, cancer, aprinocarsen, bryostatin

Abstract: As our understanding of tumorigenesis increases, interference with the various signaling pathways of tumor cells has become an attractive approach to arresting tumor cell growth and overcoming chemoresistance. Among many intracellular signaling proteins, protein kinase C (PKC) isoenzymes have been identified as possible targets to render tumor cells more susceptible to apoptosis and growth arrest. We review the known biology of the α-isoenzyme of PKC in different cancers to provide a rational approach for developing targeted therapies using PKC modulators, including aprinocarsen, an antisense oligonucleotide (ASO) against PKC-α.

Cite this article as:

Hanauske R. A-, Sundell Karen and Lahn Michael, The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen, Current Pharmaceutical Design 2004; 10 (16) . https://dx.doi.org/10.2174/1381612043384376