beta-Amyloid Aggregation Inhibitors for the Treatment of Alzheimer Disease Dream or Reality?

Patrice      Talaga

doi:10.2174/1389557013407098

Abstract

Amyloid (A beta) deposition remains a hallmark in the pathology of Alzheimer disease (AD). Important drug discovery efforts dedicated to the inhibition of the polymerization process leading to amyloid neurotoxicity are pursued by academic groups and the pharmaceutical industry as a potential preventive treatment for AD. The aim of this review is to up-date current knowledge on the amyloid aggregation process and the various available peptidic and non-peptidic A beta aggregation inhibitors.

Keywords: Aggregation Inhibitors, Alzheimers Disease, Anti-inflammatory agents, Antioxidants, Neurotrophic, Ab Aggregation Inhibition, AMYLOID AGGREGATION INHIBITORS, Thyrotrophin releasing hormone (TRH), Melatonin, Hexadecyl-N-methylpiperidinium (HMP) bromide