Analysis of Fibril Formation of Amyloid-β- Protein by Stretched Exponential Function

Title: Analysis of Fibril Formation of Amyloid-β- Protein by Stretched Exponential Function

Volume: 10 Issue: 6

Author(s): Ken-ichi Shinozaki, Takeo Konakahara, Hiroaki Okuno and Masato Kodaka

Affiliation:

Keywords: fibril formation, amyloid-b-protein, stretched exponential function, hydrophobic protein

Abstract: Kinetic behavior of aggregation of amyloid-β-protein (Aβ) is represented by a stretched exponential function, F=A{1-exp(-Btn)}. Differences in temperature-dependence of A, B and n are studied for Aβ 1-40 and Aβ 1-42. As the temperature is lowered, parameter A is increased, parameter B is decreased and parameter n is increased in Aβ 1-40, while these parameters are less sensitive to temperature in a more hydrophobic protein Aβ 1-42. ln B is a linear function of n, which is shown by ln B = -6.34n + 3.69.

Cite this article as:

Shinozaki Ken-ichi, Konakahara Takeo, Okuno Hiroaki and Kodaka Masato, Analysis of Fibril Formation of Amyloid-β- Protein by Stretched Exponential Function, Protein & Peptide Letters 2003; 10 (6) . https://dx.doi.org/10.2174/0929866033478582