Abstract
Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing inhibitors of NOS, and hundreds of inhibitors have been identified. In contrast, the study on NOS substrates is less active. The advances in the identification, design and development of NOS substrates are discussed in this review. The focus is the chemistry and biochemistry of N-hydroxyguanidines. The crystal structures of substrates bound to NOSs and the mechanisms of NOS catalyzed NO generation from substrates are also discussed.
Keywords: cgmp, nadph, inos, cyanamide, oxidation, cytotoxicity, l-arginine, michaelis-menten kinetics, peroxoiron
Current Topics in Medicinal Chemistry
Title: N-Hydroxyguanidines as Substrates of Nitric Oxide Synthases
Volume: 5 Issue: 7
Author(s): T. B. Cai, Dongning Lu and Peng G. Wang
Affiliation:
Keywords: cgmp, nadph, inos, cyanamide, oxidation, cytotoxicity, l-arginine, michaelis-menten kinetics, peroxoiron
Abstract: Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing inhibitors of NOS, and hundreds of inhibitors have been identified. In contrast, the study on NOS substrates is less active. The advances in the identification, design and development of NOS substrates are discussed in this review. The focus is the chemistry and biochemistry of N-hydroxyguanidines. The crystal structures of substrates bound to NOSs and the mechanisms of NOS catalyzed NO generation from substrates are also discussed.
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Cite this article as:
Cai B. T., Lu Dongning and Wang G. Peng, N-Hydroxyguanidines as Substrates of Nitric Oxide Synthases, Current Topics in Medicinal Chemistry 2005; 5 (7) . https://dx.doi.org/10.2174/1568026054679344
DOI https://dx.doi.org/10.2174/1568026054679344 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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