Structure-Activity Relationship Within the Serine Protease Inhibitors of the Pacifastin Family

Title: Structure-Activity Relationship Within the Serine Protease Inhibitors of the Pacifastin Family

Volume: 12 Issue: 5

Author(s): Christine Kellenberger and Alain Roussel

Affiliation:

Keywords: pacifastin, protease inhibitor, insect, structure, species selectivity

Abstract: The members of the Pacifastin family are serine protease inhibitors found in insects and crustacean. They are either small inhibitors (made of one consensus cysteine-rich motif) or proteins (4-9 motifs). Some of these inhibitors are characterized by a species selectivity for the trypsin inhibition. Structural data discriminate the small inhibitors that apparently look very similar into two groups. Interestingly, the inhibitors that display species selectivity fall in the same structural group.

Cite this article as:

Kellenberger Christine and Roussel Alain, Structure-Activity Relationship Within the Serine Protease Inhibitors of the Pacifastin Family, Protein & Peptide Letters 2005; 12 (5) . https://dx.doi.org/10.2174/0929866054395239

DOI https://dx.doi.org/10.2174/0929866054395239	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305