Abstract
The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.
Keywords: prostate cancer, anti-androgen, trifluoro-casodex analogue, nucleophilic reagents, chromatography
Letters in Organic Chemistry
Title: Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide)
Volume: 2 Issue: 5
Author(s): M. Sani, F. Viani, M. Binda, N. Zaffaroni and M. Zanda
Affiliation:
Keywords: prostate cancer, anti-androgen, trifluoro-casodex analogue, nucleophilic reagents, chromatography
Abstract: The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.
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Sani M., Viani F., Binda M., Zaffaroni N. and Zanda M., Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide), Letters in Organic Chemistry 2005; 2 (5) . https://dx.doi.org/10.2174/1570178054405850
DOI https://dx.doi.org/10.2174/1570178054405850 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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