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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Non-Steroidal Progesterone Receptor Specific Ligands

Author(s): G. F. Allan and Z. Sui

Volume 5, Issue 8, 2005

Page: [701 - 708] Pages: 8

DOI: 10.2174/1389557054553794

Price: $65

Abstract

The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.

Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone


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