Abstract
The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Mini-Reviews in Medicinal Chemistry
Title: Non-Steroidal Progesterone Receptor Specific Ligands
Volume: 5 Issue: 8
Author(s): G. F. Allan and Z. Sui
Affiliation:
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Abstract: The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Export Options
About this article
Cite this article as:
Allan F. G. and Sui Z., Non-Steroidal Progesterone Receptor Specific Ligands, Mini-Reviews in Medicinal Chemistry 2005; 5 (8) . https://dx.doi.org/10.2174/1389557054553794
DOI https://dx.doi.org/10.2174/1389557054553794 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Mast Cell Pathway to Inflammation and Homeostasis: Pharmacolo- gical Insights
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Patents and the Development on Polymer based Nanomaterial (PAMAM Dendrimer) for Biomedical Applications
Recent Patents on Biomedical Engineering (Discontinued) Inhibitors of the Hedgehog Signal Transduction Pathway
Current Cancer Therapy Reviews Next Generation Tyrosine Kinase Inhibitor (TKI): Afatinib
Recent Patents on Anti-Cancer Drug Discovery Exploring Therapeutic Potential of Nanocarrier Systems Against Breast Cancer
Pharmaceutical Nanotechnology Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin
Current Pharmaceutical Design Therapeutic Progress and Knowledge Basis on the Natriuretic Peptide System in Heart Failure
Current Topics in Medicinal Chemistry Role of Monitoring Thiopurine Methyltransferase (TPMT) Activity in the Individualized Therapy with Azathioprine or 6-Mercaptopurine
Current Pharmacogenomics and Personalized Medicine Anti-Fungal Activity of <i>Cressa cretica, Leptadenia pyrotechnica</i> and <i>Pulicaria crispa</i>, Indigenous Plants of Cholistan Desert, Pakistan
Anti-Infective Agents Intraperitoneal Chemotherapy as First-Line Treatment in the Management of Epithelial Ovarian Cancer
Mini-Reviews in Medicinal Chemistry CNS Cancer Cell Line Cytotoxicity Profiles of Some 2, 6, 9-Substituted Purines: A Comparative Five-Dose Testing Study
Letters in Drug Design & Discovery Gallium-68 in Medical Imaging
Current Radiopharmaceuticals Glycans in Magnetic Resonance Imaging: Determinants of Relaxivity to Smart Agents, and Potential Applications in Biomedicine
Current Medicinal Chemistry Aptamer-Mediated Polymeric Vehicles for Enhanced Cell-Targeted Drug Delivery
Current Drug Targets Pharmacogenetics of Drug Transporters
Current Pharmaceutical Design ABC Transporters in Extrahepatic Tissues: Pharmacological Regulation in Heart and Intestine
Current Medicinal Chemistry Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors
Mini-Reviews in Medicinal Chemistry Nuclear Architecture and Gene Expression in the Quest for Novel Therapeutics
Current Pharmaceutical Design Preface
Drug Delivery Letters Cancer Resistance to Type II Topoisomerase Inhibitors
Current Medicinal Chemistry