Abstract
The new germanium compounds of cinnamic acid, RC6H4CHGe(OCH2CH2)3NCH2COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
Keywords: Germanium, cinnamic acid, hydroxyl-cinnamic acid germanium, synthesis, trichlorogermane, germatrane, u14 tumor-cell, antitumor activity, tumor inhibitory
Medicinal Chemistry
Title: Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids
Volume: 3 Issue: 5
Author(s): Lianbao Ye and Wanjin Zhang
Affiliation:
Keywords: Germanium, cinnamic acid, hydroxyl-cinnamic acid germanium, synthesis, trichlorogermane, germatrane, u14 tumor-cell, antitumor activity, tumor inhibitory
Abstract: The new germanium compounds of cinnamic acid, RC6H4CHGe(OCH2CH2)3NCH2COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
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Cite this article as:
Ye Lianbao and Zhang Wanjin, Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids, Medicinal Chemistry 2007; 3 (5) . https://dx.doi.org/10.2174/157340607781745465
DOI https://dx.doi.org/10.2174/157340607781745465 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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