Abstract
K+ channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate (ATP)-sensitive K+ (KATP) channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics. Although accumulated evidence suggests that many anesthetics modify the above function of K+ channels as a metabolic sensor, further studies are certainly needed to resolve certain issues, especially in clinical settings of anesthesia use.
Keywords: ATP-sensitive K+ channels, oxidative stress, vascular smooth muscle cell, endothelium, vascular function, cerebral vasculature, anesthetics.
Current Pharmaceutical Design
Title:Protective Effects of Anesthetics on Vascular Function Related to K+ Channels
Volume: 20 Issue: 36
Author(s): Shinji Kawahito, Katsutoshi Nakahata, Toshiharu Azma, Yasuhiro Kuroda, David J. Cook and Hiroyuki Kinoshita
Affiliation:
Keywords: ATP-sensitive K+ channels, oxidative stress, vascular smooth muscle cell, endothelium, vascular function, cerebral vasculature, anesthetics.
Abstract: K+ channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate (ATP)-sensitive K+ (KATP) channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics. Although accumulated evidence suggests that many anesthetics modify the above function of K+ channels as a metabolic sensor, further studies are certainly needed to resolve certain issues, especially in clinical settings of anesthesia use.
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Cite this article as:
Kawahito Shinji, Nakahata Katsutoshi, Azma Toshiharu, Kuroda Yasuhiro, Cook J. David and Kinoshita Hiroyuki, Protective Effects of Anesthetics on Vascular Function Related to K+ Channels, Current Pharmaceutical Design 2014; 20 (36) . https://dx.doi.org/10.2174/1381612820666140204115647
DOI https://dx.doi.org/10.2174/1381612820666140204115647 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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