Central Nervous System Manifestations in Systemic Lupus Erythematosus

Title: Central Nervous System Manifestations in Systemic Lupus Erythematosus

Volume: 3 Issue: 3

Author(s): Simone Appenzeller, Lilian Tereza Lavras Costallat and Fernando Cendes

Affiliation:

Keywords: CNS involvement, SLE

Abstract: Neurologists and rheumatologist are often called to evaluate central nervous system (CNS) manifestations in patients with suspected or definite systemic lupus erythematosus (SLE). The manifestations are highly diverse and often have major prognostic consequences. The major difficulties are to determine if the given manifestation is primarily due to SLE activity in the brain, or a consequence of metabolic disturbances, infection, or corticosteroid use. The true incidence of CNS manifestations attributable to SLE is not entirely clear, but several studies show prevalence rate between 15-75%, depending on different methods and classification criteria applied. This paper has the objective to review the main clinical manifestations according to American College of Rheumatology (ACR) criteria, possible etiological mechanisms and neuroimaging features associated with these manifestations. We further discuss the most important tools that can help bedside diagnosis.

Cite this article as:

Simone Appenzeller , Lilian Tereza Lavras Costallat and Fernando Cendes , Central Nervous System Manifestations in Systemic Lupus Erythematosus, Current Rheumatology Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339707781387572

DOI https://dx.doi.org/10.2174/157339707781387572	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360