Abstract
Quinolones are one of the most important classes of antimicrobial agents discovered in the recent years and one of the most widely used classes of antibiotics in clinical medicine. Their broad spectrum of activity and pharmacokinetic properties make them ideal agents for treating a variety of infections. Their clinical importance is further demonstrated by their activity against a wide range of diseases of public health importance such as anthrax, tuberculosis, bacterial pneumonia, and sexually transmitted diseases. Like other antibiotics, quinolones can cause various, sometimes dangerous hypersensitivity reactions. The underlying pathomechanisms are only poorly understood. Some are thought to be partly non-immune mediated reactions, others are considered to be IgE- or T cell-mediated reactions. This review gives an insight into the different immunological mechanisms leading to the diverse symptoms of quinolone-induced hypersensitivity reactions, with special emphasis on the role of T cells in such reactions.
Keywords: Quinolones, Hypersensitivity, IgE-mediated, T cell-mediated, Crossreactivity
Current Pharmaceutical Design
Title: Hypersensitivity Reactions to Quinolones
Volume: 12 Issue: 26
Author(s): Daphne Anne Schmid, Paolo Campi and Werner Joseph Pichler
Affiliation:
Keywords: Quinolones, Hypersensitivity, IgE-mediated, T cell-mediated, Crossreactivity
Abstract: Quinolones are one of the most important classes of antimicrobial agents discovered in the recent years and one of the most widely used classes of antibiotics in clinical medicine. Their broad spectrum of activity and pharmacokinetic properties make them ideal agents for treating a variety of infections. Their clinical importance is further demonstrated by their activity against a wide range of diseases of public health importance such as anthrax, tuberculosis, bacterial pneumonia, and sexually transmitted diseases. Like other antibiotics, quinolones can cause various, sometimes dangerous hypersensitivity reactions. The underlying pathomechanisms are only poorly understood. Some are thought to be partly non-immune mediated reactions, others are considered to be IgE- or T cell-mediated reactions. This review gives an insight into the different immunological mechanisms leading to the diverse symptoms of quinolone-induced hypersensitivity reactions, with special emphasis on the role of T cells in such reactions.
Export Options
About this article
Cite this article as:
Anne Schmid Daphne, Campi Paolo and Joseph Pichler Werner, Hypersensitivity Reactions to Quinolones, Current Pharmaceutical Design 2006; 12 (26) . https://dx.doi.org/10.2174/138161206778194033
DOI https://dx.doi.org/10.2174/138161206778194033 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds
Current Topics in Medicinal Chemistry Susceptibility of Periodontopathogenic and Cariogenic Bacteria to Defensins and Potential Therapeutic Use of Defensins in Oral Diseases
Current Pharmaceutical Design Editorial
Current Molecular Medicine Rational Design and Evaluation of the Recombinant Multiepitope Protein for Serodiagnosis of Rubella
Current Pharmaceutical Biotechnology Recent Patents on DNA Sequences and Diagnostic Methods for the Identification and Strain Differentiation of Mycobacterium Tuberculosis
Recent Patents on DNA & Gene Sequences Clinical Presentations and Diagnosis of Brucellosis
Recent Patents on Anti-Infective Drug Discovery Drug Approval Process – In United States of America, European Union and India: A Review
Applied Clinical Research, Clinical Trials and Regulatory Affairs Editorial (Thematic Issue: New Antimicrobial Therapeutics)
Current Medicinal Chemistry Ultra-Sensitive Electrochemical Sensor for the Determination of Pyrazinamide
Current Analytical Chemistry pH-dependent Activities and Structural Stability of Loop-2-anchoring Helix of RadA Recombinase from Methanococcus voltae
Protein & Peptide Letters Vascular Wall-Related Biomarkers in Sepsis: A Review of Current Evidence and a Critical Appraisal of Recent Patents
Recent Patents on Biomarkers Hypocholesterolemia
Current Vascular Pharmacology Identification of Drug Targets in Helicobacter pylori by in silico Analysis : Possible Therapeutic Implications for Gastric cancer
Current Cancer Drug Targets Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides
Current Medicinal Chemistry Current Status Of Short Synthetic Peptides As Vaccines
Medicinal Chemistry Medicolegal Aspects of Disclosure of Side Effects of Biologic Drugs in Rheumatology: A Pilot Study
New Emirates Medical Journal Meet Our Editorial Board Member
Current Respiratory Medicine Reviews Cellular and Molecular Mechanisms of Tumor-Induced T-Cell Tolerance
Current Cancer Drug Targets Meet the Editorial Board Member
Current Pharmaceutical Biotechnology Immune Response to Mycobacteria
Current Immunology Reviews (Discontinued)