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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and In Vitro Biochemical Evaluation of a Series of Cycloalkyl Esters of 4-Sulfamoylated Benzoic Acid as Inhibitors of Estrone Sulfatase (ES)

Author(s): Caroline P. Owen, Chirag K. Patel, Tim Cartledge and Sabbir Ahmed

Volume 4, Issue 6, 2007

Page: [399 - 403] Pages: 5

DOI: 10.2174/157018007781387845

Price: $65

Abstract

We report the results of the synthesis and biochemical evaluation of esters of 4-[(aminosulfonyl)oxy]benzoate as potential inhibitors of estrone sulfatase (ES). Modelling the compounds shows that steric interaction between the inhibitor and the active site is a major factor responsible for the weak inhibitory activity observed within the synthesised compounds.

Keywords: Estrone sulfatase, Synthesis, Evaluation, Cycloalkyl esters, Breast cancer, Inhibition


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