Heme Oxygenase-1: A Fundamental Guardian Against Oxidative Tissue Injuries in Acute Inflammation

Title: Heme Oxygenase-1: A Fundamental Guardian Against Oxidative Tissue Injuries in Acute Inflammation

Volume: 7 Issue: 7

Author(s): T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita, S. Sassa, T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita and S. Sassa

Affiliation:

Keywords: Carbon monoxide, heme, heme oxygenase-1, inflammation, liver injury, oxidative stress, renal injury, sepsis

Abstract: Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO- 1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

Cite this article as:

T. Takahashi , H. Shimizu , H. Morimatsu , K. Inoue , R. Akagi , K. Morita , S. Sassa , Takahashi T., Shimizu H., Morimatsu H., Inoue K., Akagi R., Morita K. and Sassa S., Heme Oxygenase-1: A Fundamental Guardian Against Oxidative Tissue Injuries in Acute Inflammation, Mini-Reviews in Medicinal Chemistry 2007; 7 (7) . https://dx.doi.org/10.2174/138955707781024517