Abstract
Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3-Azido-3-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.
Keywords: Steroidal conjugate, AZT, phosphate, cytotoxic activity
Letters in Organic Chemistry
Title: Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine
Volume: 4 Issue: 3
Author(s): Peiyuan Jin, Sanhao Ji, Yong Ju and Yufen Zhao
Affiliation:
Keywords: Steroidal conjugate, AZT, phosphate, cytotoxic activity
Abstract: Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3-Azido-3-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.
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Cite this article as:
Jin Peiyuan, Ji Sanhao, Ju Yong and Zhao Yufen, Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737336
DOI https://dx.doi.org/10.2174/157017807780737336 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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