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Recent Patents on CNS Drug Discovery (Discontinued)

Editor-in-Chief

ISSN (Print): 1574-8898
ISSN (Online): 2212-3954

Glutamatergic Dysfunction-Newer Targets for Anti-Obsessional Drugs

Author(s): Sagnik Bhattacharyya and Koushik Chakraborty

Volume 2, Issue 1, 2007

Page: [47 - 55] Pages: 9

DOI: 10.2174/157488907779561727

Price: $65

Abstract

Despite widespread use and validation of their efficacy, about 40-60% of obsessive compulsive disorder (OCD) sufferers do not respond to appropriate courses of treatment with serotonin reuptake inhibitors (SRI) and even with the combination of pharmacotherapy and cognitive behaviour therapy a substantial number of patients remain dramatically symptomatic. Recently, there has been increasing interest in investigating glutamatergic dysfunction in OCD. Multiple lines of evidence point toward glutamatergic dysfunction being related to the pathophysiology of OCD, with glutamate modulating drugs being an alternative pharmacological strategy for treating OCD. In this article we focus in detail on the rationale for targeting glutamatergic agents as well as review the recent important patents for compounds that have emerged from these studies.

Keywords: Glutamate, serotonin, obsessive compulsive disorder, metabotropic glutamate receptor antagonist


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