Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis

Title: Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis

Volume: 6 Issue: 4

Author(s): Volker Vielhauer and Hans-Joachim Anders

Affiliation:

Keywords: Chemokine, chemokine receptors, systemic lupus erythematosus, MRL/lpr mouse, leukocyte recruitment, kidney, polymorphism

Abstract: Pro-inflammatory chemokines are important mediators of inflammation and autoimmune injury. The spatial and temporal expression of chemokines and chemokine receptors in the nephritic kidney suggests that targeting the chemokine system may represent a valuable approach for anti-inflammatory therapy of lupus nephritis. In this review we summarize the available data on the pathogenic role of chemokines and chemokine receptors in lupus nephritis and particularly focus on epidemiological data in lupus patients and interventional studies with chemokine or chemokine receptor antagonists in experimental lupus.

Cite this article as:

Vielhauer Volker and Anders Hans-Joachim, Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis, Endocrine, Metabolic & Immune Disorders - Drug Targets 2006; 6 (4) . https://dx.doi.org/10.2174/187153006779025739