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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Asymmetric Synthesis of the β-Hydroxy Acid Segment of Hapalosin (EXPERIMENTAL)

Author(s): Anubha Sharma, Siddharth Roy, Dibakar Goswami, Angshuman Chattopadhyay and Subrata Chattopadhyay

Volume 3, Issue 10, 2006

Page: [741 - 743] Pages: 3

DOI: 10.2174/157017806779025997

Price: $65

Abstract

A facile synthesis of the title compound has been developed starting from the crotylated product of (R)-cyclohexylideneglyceraldehyde (2). The key features of the synthesis were stereochemical control of the crotylation by alteration of reaction conditions, operational simplicity and the use of inexpensive compounds/reagents.

Keywords: Asymmetric synthesis, (R)-cyclohexylideneglyceraldehyde, hapalosin, β-hydroxy acid


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