Adenosine-to-Inosine RNA Editing: Perspectives and Predictions

Barry      Hoopengardner

doi:10.2174/138955706778742812

Abstract

Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.

Keywords: Adenosine, inosine, RNA, editing, drosophila, ion channel, convergence

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