Abstract
The Global Initiative for Chronic Obstructive Lung Disease guidelines stated that COPD is a disease of airflow limitation that is associated with abnormal inflammatory response. Targeting inflammation and improving airflow is a central goal to treat this disease. Corticosteroids are currently the most popular anti-inflammatory agents for obstructive airway disease. Several long-acting bronchodilators are available to improve airflow. Suppression of inflammation in the asthmatic airway is associated with an increase of expiratory flow. In COPD, the relation between inflammation and airflow limitation is not as clear as that in asthma. Understanding the characters of inflammation and the pathogenesis of airflow limitation may help to provide optimal treatment for patients with COPD.
Keywords: Neutrophils, anti-inflammatory, corticosteroids, T Lymphocytes, matrix metalloproteases, bronchodilator reversibility
Current Respiratory Medicine Reviews
Title: Airway Inflammation and Airflow Limitation in COPD
Volume: 2 Issue: 4
Author(s): Diahn-Warng Perng, Kang-Cheng Su and Lung-Yu Liu
Affiliation:
Keywords: Neutrophils, anti-inflammatory, corticosteroids, T Lymphocytes, matrix metalloproteases, bronchodilator reversibility
Abstract: The Global Initiative for Chronic Obstructive Lung Disease guidelines stated that COPD is a disease of airflow limitation that is associated with abnormal inflammatory response. Targeting inflammation and improving airflow is a central goal to treat this disease. Corticosteroids are currently the most popular anti-inflammatory agents for obstructive airway disease. Several long-acting bronchodilators are available to improve airflow. Suppression of inflammation in the asthmatic airway is associated with an increase of expiratory flow. In COPD, the relation between inflammation and airflow limitation is not as clear as that in asthma. Understanding the characters of inflammation and the pathogenesis of airflow limitation may help to provide optimal treatment for patients with COPD.
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Cite this article as:
Perng Diahn-Warng, Su Kang-Cheng and Liu Lung-Yu, Airway Inflammation and Airflow Limitation in COPD, Current Respiratory Medicine Reviews 2006; 2 (4) . https://dx.doi.org/10.2174/157339806778777267
DOI https://dx.doi.org/10.2174/157339806778777267 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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