Abstract
The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.
Keywords: Antibiotics, drug resistance, biofilm, virulence, efflux, synergy, antisense, fragment based drug design, screening, mutants
Current Drug Targets
Title: Screening Strategies to Identify New Antibiotics
Volume: 13 Issue: 3
Author(s): Mark S. Butler and Matthew A. Cooper
Affiliation:
Keywords: Antibiotics, drug resistance, biofilm, virulence, efflux, synergy, antisense, fragment based drug design, screening, mutants
Abstract: The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.
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Cite this article as:
S. Butler Mark and A. Cooper Matthew, Screening Strategies to Identify New Antibiotics, Current Drug Targets 2012; 13 (3) . https://dx.doi.org/10.2174/138945012799424624
DOI https://dx.doi.org/10.2174/138945012799424624 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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