The PD-1/PD-L1 Pathway in Human Pathology

Title: The PD-1/PD-L1 Pathway in Human Pathology

Volume: 12 Issue: 3

Author(s): M. Saresella, V. Rainone, N. M. Al-Daghri, M. Clerici and D. Trabattoni

Affiliation:

Keywords: Alzheimer's disease, autoimmunity, costimulation, HIV infection, immune tolerance, multiple sclerosis, PD-1, PD-L1, T-cell activation, immune system, microbial pathogens, antigens, antigenic peptide/major histocompatibility complex, costimulatory signals, phenotype

Abstract: T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.

Cite this article as:

Saresella M., Rainone V., M. Al-Daghri N., Clerici M. and Trabattoni D., The PD-1/PD-L1 Pathway in Human Pathology, Current Molecular Medicine 2012; 12 (3) . https://dx.doi.org/10.2174/156652412799218903