Abstract
Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barre Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
Keywords: Intravenous immunoglobulins, mechanisms of action, inflammatory neuropathy, Guillain Barre syndrome, Chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy
Current Neuropharmacology
Title: Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies
Volume: 7 Issue: 4
Author(s): Saiju Jacob and Yusuf A. Rajabally
Affiliation:
Keywords: Intravenous immunoglobulins, mechanisms of action, inflammatory neuropathy, Guillain Barre syndrome, Chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy
Abstract: Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barre Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
Export Options
About this article
Cite this article as:
Jacob Saiju and Rajabally A. Yusuf, Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies, Current Neuropharmacology 2009; 7 (4) . https://dx.doi.org/10.2174/157015909790031166
DOI https://dx.doi.org/10.2174/157015909790031166 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Meet Our Editorial Board Member:
Current Rheumatology Reviews Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets Spontaneous (Autoimmune) Chronic Urticaria in Children: Current Evidences, Diagnostic Pitfalls and Therapeutic Management
Recent Patents on Inflammation & Allergy Drug Discovery Pharmacogenomics: A Tool to Prevent and Cure Coronary Heart Disease
Current Pharmaceutical Design Vasopressin Secretion Control: Central Neural Pathways, Neurotransmitters and Effects of Drugs
Current Pharmaceutical Design CT Findings of Pulmonary Metastases from Primary Cardiac Angiosarcoma
Current Medical Imaging Cholesterol Lowering Therapy: Treat to Target or Reduce the Global Risk? The Unresolved Problem of Residual Risk
Current Pharmaceutical Design Oxidative-Nitrosative Stress In Hypertension
Current Vascular Pharmacology Controversies in Pharmacological Treatment of Inflammatory Component of Macular Edema
Current Pharmaceutical Design The Role of Protease-Activated Receptors for the Development of Myocarditis: Possible Therapeutic Implications
Current Pharmaceutical Design Catastrophic Antiphospholipid Syndrome - 20 Years Later
Current Rheumatology Reviews Macrophages in Inflammation
Current Drug Targets - Inflammation & Allergy Features of Bioaccumulation and Toxic Effects of Copper (II) Oxide Nanoparticles Under Repeated Oral Exposure in Rats
Pharmaceutical Nanotechnology The Physicochemical and Pharmacokinetic Relationships of Barbiturates – From the Past to the Future
Current Pharmaceutical Design Regulation of Platelet Function by Acetylation/Deacetylation Mechanisms
Current Medicinal Chemistry Phenolic Compounds in Prevention and Treatment of Skin Cancers: A Review
Current Medicinal Chemistry Childhood Systemic Lupus Erythematosus: New and Old Treatments
Current Pediatric Reviews Small Ruminant Lentiviruses and Human Immunodeficiency Virus: Cousins that Take a Long View
Current HIV Research A Systematic Approach to Hypertensive Urgencies and Emergencies
Current Hypertension Reviews HSP60 as a Drug Target
Current Pharmaceutical Design