Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

Title: Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

Volume: 17 Issue: 38

Author(s): Adam Lesner, Anna Legowska, Magdalena Wysocka and Krzysztof Rolka

Affiliation:

Keywords: SFTI-1, inhibitor, serine proteinases, peptidomimetics, peptomers, analogs, pharmaceutical agents, cytotoxicity, trypsin, chymotrypsin

Abstract: This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.

Cite this article as:

Lesner Adam, Legowska Anna, Wysocka Magdalena and Rolka Krzysztof, Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery, Current Pharmaceutical Design 2011; 17 (38) . https://dx.doi.org/10.2174/138161211798999393