Abstract
Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.
Keywords: Azines, benzopyran, chromene, coumarin, drug-like scaffolds, heterocycles, multicomponent reactions, privileged structures, pyridine, synthetic methods
Current Medicinal Chemistry
Title: Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry
Volume: 18 Issue: 31
Author(s): L. J. Nunez-Vergara, J. A. Squella, P. A. Navarrete-Encina, E. Vicente-Garcia, S. Preciado and R. Lavilla
Affiliation:
Keywords: Azines, benzopyran, chromene, coumarin, drug-like scaffolds, heterocycles, multicomponent reactions, privileged structures, pyridine, synthetic methods
Abstract: Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with emphasis on multicomponent reactions and robust methodologies. Reactivity issues, medicinal applications and other properties are also reviewed.
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Cite this article as:
J. Nunez-Vergara L., A. Squella J., A. Navarrete-Encina P., Vicente-Garcia E., Preciado S. and Lavilla R., Chromenopyridines: Promising Scaffolds for Medicinal and Biological Chemistry, Current Medicinal Chemistry 2011; 18 (31) . https://dx.doi.org/10.2174/092986711797535272
DOI https://dx.doi.org/10.2174/092986711797535272 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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